Gerry Gajadharsingh writes:

“With the general population getting older, and usually for most getting sicker and with more and more elderly people are being prescribed multiple medications, it’s useful to be reminded of the pros and cons of medication especially in the elderly. I have blogged on several previous occasions about the risk of polypharmacy (taking multiple medications), especially in the elderly, and even Professor Sir Chris Whitty, England’s Chief Medical Officer, has flagged this up in an article in The Times recently.

 “He said many older people were on dozens of drugs, some of which could be unnecessary and causing side effects. “There’s always a trade-off,” he said. “One of the things geriatricians are often very good at doing is meeting this person who’s on 25 drugs and just going through it and saying, ‘Actually you just don’t need to have at least half of these. At this point in your life, this is not going to help you, the side effects cumulatively are going to be quite problematic’.”

 Launching his annual report, Professor Sir Chris Whitty urged people to adopt “old fashioned” habits to stave off ill health and disability in later life, saying sickness need not be an inevitable part of ageing. He said healthy eating, exercise, mental stimulation, drinking only in moderation and stopping smoking were key.

 Below is a recent article from Medscape from an American MD, giving his view on the common medications that need to be considered carefully when being prescribed to the elderly, the definition they are using is for people over age 65.”

Medscape

Neil Skolnik, MD

I’m Dr Neil Skolnik. Today we are going to talk about the American geriatrics Society 2023 updated Beers criteria guidance for medication use in older adults. These criteria have been updated and revised approximately every 5 years since 1991 and serve to alert us to medications for which the risk-benefit ratio is not as good in older adults as in the rest of the population.

These are important criteria because medications are metabolized differently in older adults and have different effects compared with younger patients. For the sake of these criteria, older adults are 65 years of age or older. That said, we know that everyone from 65 to 100 is not the same. As people age, they develop more comorbidities, they become more frail, and they are more sensitive to the effects and side effects of drugs.

The guidance covers potentially inappropriate medications for older adults. The word “potentially” is important because this is guidance. As clinicians, we make decisions involving individuals. This guidance should be used with judgment, integrating the clinical context of the individual patient.

There is a lot in this guidance. I am going to try to cover what I feel are the most important points.

Aspirin. Since the risk for major bleeding increases with age, for primary prevention of atherosclerotic cardiovascular disease (furring of the arteries) the harm can be greater than the benefit in older adults, so aspirin should not be used for primary prevention. Aspirin remains indicated for secondary prevention in individuals with established cardiovascular disease.

Warfarin. For treatment of atrial fibrillation or venous thromboembolism (deep vein thrombosis or pulmonary embolism), warfarin should be avoided if possible. Warfarin has a higher risk for major bleeding, particularly intracranial bleeding, than direct oral anticoagulants (DOACs); therefore, the latter are preferred. Rivaroxaban should be avoided, as it has a higher risk for major bleeding in older adults than the other DOACs. Apixaban is preferred over dabigatran. If a patient is well controlled on warfarin, you can consider continuing that treatment.

Antipsychotics. These include first- and second-generation antipsychotics such as aripiprazole, haloperidol, olanzapine, quetiapine, risperidone and others. The guidance says to avoid these agents except for FDA-approved indications such as schizophrenia, bipolar disorder, and adjuvant treatment of depression. Use of these antipsychotics can increase risk for stroke, heart attack, and mortality. Essentially, the guidance says do not use these medications lightly for the treatment of agitated dementia. For those of us with older patients, this can get tricky because agitated dementia is a difficult issue for which there are no good effective medications. The Beers guidance recognizes this in saying that these medications should be avoided unless behavioural interventions have failed. So, there are times where you may need to use these medicines but use them judiciously.

For patients with dementia, anticholinergics, antipsychotics, and benzodiazepines should be avoided if possible.

Benzodiazepines. Benzodiazepines should also be avoided because older adults have increased sensitivity to the effects of benzodiazepines due to slower metabolism and clearance of these medications, which can lead to a much longer half-life and higher serum level. In older adults, benzodiazepines increase the risk for cognitive impairment, delirium, falls, fractures, and even motor accidents. The same concerns affect the group of non-benzodiazepines sleeping medicines known as “Z-drugs.”

Nonsteroidal anti-inflammatory drugs (NSAIDs). Used frequently in our practices, NSAIDs are nevertheless on the list. As we think through the risk-benefit ratio of using NSAIDs in older adults, we often underappreciate the risks of these agents. Upper gastrointestinal ulcers with bleeding occur in approximately 1% of patients treated for 3-6 months with an NSAID and in 2%-4% of patients treated for a year. NSAIDs also increase the risk for renal impairment and cardiovascular disease (and often pushes up blood pressure)

Other medications to avoid (if possible). These include:

  • Sulfonylureas (glucose control), due to a high risk for hypoglycaemia. A short-acting sulfonylurea, such as glipizide, should be used if one is needed.
  • Proton pump inhibitors should not be used long-term if it can be avoided.
  • Digoxin should not be first-line treatment for atrial fibrillation or heart failure. Decreased renal clearance in older adults can lead to toxic levels of digoxin, particularly during acute illnesses. Avoid doses > 0.125 mg/day.
  • Nitrofurantoin (an antibiotic usually used to treat bacterial infection in the urinary tract) should be avoided when the patient’s creatinine clearance is < 30 or for long-term suppressive therapy.
  • Avoid combining medications that have high anticholinergic side effects, such as scopolamine (anti-nausea drug), diphenhydramine (sedating antihistamine), oxybutynin (anti-cholinergic drug for bladder overactivity), cyclobenzaprine (a muscle relaxant related to tricyclic antidepressants)and others.

It is always important to understand the benefits and the risks of the drugs we prescribe. It is also important to remember that older adults are a particularly vulnerable population. The Beers criteria provide important guidance which we can then use to make decisions about medicines for individual patients.